Factores asociados a severidad y mortalidad en pacientes con COVID-19: estudio multicéntrico en República Dominicana
Issue | Vol. 7 Núm. 2 (2023): Ciencia y Salud, abril-junio |
DOI | |
Publicado | jun 3, 2023 |
Estadísticas |
Resumen
Objetivo: identificar factores asociados a severidad y mortalidad por COVID-19.
Material y métodos: estudio observacional multicéntrico retrospectivo de pacientes ingresados por COVID-19 en centros de una ciudad de la República Dominicana. Se reportaron datos demográficos, clínicos, terapéuticos y de laboratorio para su comparación entre pacientes con enfermedad severa y no severa, fallecidos y dados de alta.
Resultados: los factores asociados a mayor riesgo de severidad y mortalidad fueron el sexo masculino, la hipertensión arterial, la cantidad de comorbilidades, el uso de fármacos previos, niveles elevados de marcadores inflamatorios, linfopenia, neutrofilia, entre otros. Mientras que el uso de inhibidores de la enzima convertidora de angiotensina se asoció a menor mortalidad.
Conclusiones: la identificación de los factores asociados a progresión severa y mortal por COVID-19 contribuye a la toma temprana de decisiones relacionadas a la hospitalización y a pautas de manejo médico diferencial en quienes conllevan mayor riesgo de desenlaces adversos.
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Afiliaciones
Franklyn Colón
Clínica Corominas, República Dominicana
Elías Sebelén
Hospital Metropolitano de Santiago, República Dominicana
Natalia García
Clínica Universitaria Unión Médica del Norte, República Dominicana
Lisnaldy Ramírez
Pontificia Universidad Católica Madre y Maestra, República Dominicana
Kelsie Pereyra-Bencosme
Pontificia Universidad Católica Madre y Maestra, República Dominicana
Coral Vargas
Pontificia Universidad Católica Madre y Maestra, República Dominicana
Fiodor Tejada
Pontificia Universidad Católica Madre y Maestra, República Dominicana
Guillermo Taveras
Pontificia Universidad Católica Madre y Maestra, República Dominicana
Anthony Gutiérrez-Martínez
Pontificia Universidad Católica Madre y Maestra, República Dominicana