SARS-CoV-2 y hemoglobina: análisis estructural y perspectivas de la vida real
Issue | Vol. 5 Núm. 3 (2021): Ciencia y Salud, septiempre-diciembre |
DOI | |
Publicado | oct 13, 2021 |
Estadísticas |
Resumen
La enfermedad por Coronavirus 2019 (COVID-19) ha resultado en una pandemia nueva y de rápido crecimiento causada por el coronavirus del síndrome respiratorio agudo severo 2 (SARS-CoV-2). La comprensión de la base fisiopatológica e inmunológica detrás de las manifestaciones clínicas es esencial para el desarrollo de terapias efectivas en pacientes infectados. Informes recientes han descrito una correlación clínica y molecular entre el SARS-CoV-2 y la hemoglobina, por lo que en este estudio se proporciona una descripción estructural de la hemoglobina y una descripción molecular del SARS-CoV-2, al igual que inferencias sobre las características fisiopatológicas del virus y los hallazgos clínicos relacionados con los componentes estructurales de la hemoglobina.
Majeed A, Shajar MA. Is hemoglobin the missing link in the pathogenesis of COVID-19? Anaesthesia, Pain & Intensive Care. 2020; 7;24(1):9-12.
Helliwell J, Bolton W, Burke J, Tiernan J, Jayne D, Chapman S. Global academic response to COVID-19: Cross‐sectional study. Learned Publishing. 2020;33(4):385-93.
Sun S, Cai X, Wang H, He G, Lin Y, Lu B et al. Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China. Clinica Chimica Acta. 2020;507:174-80.
Wang Z, Du Z, Zhu F. Glycosylated hemoglobin is associated with systemic inflammation, hypercoagulability, and prognosis of COVID-19 patients. Diabetes Research and Clinical Practice. 2020 Jun 1;164:108214.
McCloskey K, Meenan J, Hall R, Tsitsikas D. COVID‐19 infection and sickle cell disease: a UK centre experience. British Journal of Haematology. 2020;190(2).
Cavezzi A, Troiani E, Corrao S. COVID-19: Hemoglobin, Iron, and Hypoxia beyond Inflammation. A Narrative Review. Clinics and Practice. 2020;10(2):24-30.
Gomes A, Neves M, Cavaleiro J. Cancer, Photodynamic Therapy And Porphyrin-Type Derivatives. Anais Da Academia Brasileira De Ciências. 2018;90(1 Suppl 2):993-1026.
Caughey WS, Ibers JA. Crystal and molecular structure of the free base porphyrin, protoporphyrin IX dimethyl ester. Journal of the American Chemical Society. 1977 Sep;99(20):6639-45.
Sepúlveda, Vizcaíno P. Estudio de la excreción urinaria de porfirinas por diferentes técnicas analíticas: aspectos cuanti-y cualitativos. Universidad Complutense de Madrid, Servicio de Publicaciones, Madrid, España; 2003.
Peñuela OA. Hemoglobina: una molécula modelo para el investigador. Colombia Médica. 2005;36(3):215-25.
Perutz M. Mechanisms Regulating The Reactions Of Human Hemoglobin With Oxygen And Carbon Monoxide. Annual Review of Physiology. 1990;52(1):1-25.
Thom C, Dickson C, Gell D, Weiss M. Hemoglobin Variants: Biochemical Properties and Clinical Correlates. Cold Spring Harbor Perspectives in Medicine. 2013;3(3):a011858-a011858.
Berg J, Tymoczko J, Stryer L, Gatto G. Biochemistry. 7th ed. New York: W. H. Freeman and Company; 2012.
Dickerson R, Geis I. Hemoglobin. Menlo Park, Calif.: Benjamin/Cummings Pub. Co.; 1983.
Domingues-Hamdi, E., Vasseur, C., Fournier, J., Marden, M., Wajcman, H. and Baudin-Creuza, V. Role of α-Globin H Helix in the Building of Tetrameric Human Hemoglobin: Interaction with α-Hemoglobin Stabilizing Protein (AHSP) and Heme Molecule. PLoS ONE, 2014;9(11): p.e111395.
Matsuoka M, Fujita A, Kawai Y, Kikuchi T. Similar Structures to the E-to-H Helix Unit in the Globin-Like Fold are Found in Other Helical Folds. Biomolecules. 2014;4(1):268-88.
Giardine B, Borg J, Viennas E, Pavlidis C, Moradkhani K, Joly P et al. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Research. 2013;42:D1063-D1069.
Akinsheye I, Alsultan A, Solovieff N, Ngo D, Baldwin C, Sebastiani P et al. Fetal hemoglobin in sickle cell anemia. Blood. 2011;118(1):19-27.
Frier, J. and Perutz, M. Structure of human foetal deoxyhaemoglobin. Journal of Molecular Biology, 1997;112(1):97-112.
Perutz, M. Hemoglobin Structure and Respiratory Transport. (1 ed). Scientific American. 1978;239(6):92-125.
Shaanan, B. Structure of human oxyhaemoglobin at 2·1 resolution. Journal of Molecular Biology; 1983.
Rossmann M. Atlas of molecular structures in biology. Vol. 2. Haemoglobin and myoglobin by G. Fermi and M. F. Perutz. Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 1982;38(7):2096-7.
Mousavizadeh L, Ghasemi S. Genotype and phenotype of COVID-19: Their roles in pathogenesis. Journal of Microbiology, Immunology and Infection. 2021;54(2):159-63.
Bar-On Y, Flamholz A, Phillips R, Milo R. SARS-CoV-2 (COVID-19) by the numbers. eLife. 2020;9.
Wu Y, Guo C, Tang L, Hong Z, Zhou J, Dong X et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. The Lancet Gastroenterology & Hepatology. 2020;5(5):434-5.
Smith, E. C., & Denison, M. R. (2012). Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses. Current Opinion in Virology, 2(5):519–24.
Oguh C, Obiwulu E, Wisdom O, Uchechukwu O. Structure and Function of COVID-19 Encode Proteins in the Transcription and Replication Mechanism with Its Preventive Measures and Propose Efficacy Treatments: A Critical Systematic Review. 2020;3(1):15-29.
Boopathi S, Poma A, Kolandaivel P. Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment. Journal of Biomolecular Structure and Dynamics. 2020:1-10.
Neuman B, Kiss G, Kunding A, Bhella D, Baksh M, Connelly S et al. A structural analysis of M protein in coronavirus assembly and morphology. Journal of Structural Biology. 2011;174 (1):11-22.
Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A et al. Cell entry mechanisms of SARS-CoV-2. Proceedings of the National Academy of Sciences. 2020;117(21):11727-34.
Hadadi A, Mortezazadeh M, Kolahdouzan K, Alavian G. Does recombinant human erythropoietin administration in critically ill COVID‐19 patients have miraculous therapeutic effects? Journal of Medical Virology. 2020;92(7):915-8.
Lu G, Wang J. Dynamic changes in routine blood parameters of a severe COVID-19 case. Clinica Chimica Acta. 2020;508:98-102.
Mitra A, Dwyre D, Schivo M, Thompson G, Cohen S, Ku N et al. Leukoerythroblastic reaction in a patient with COVID ‐19 infection. American Journal of Hematology. 2020; 95(8):999-1000.
Read R. Flawed methods in “COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism”;2020.
Rees D, Williams T, Gladwin M. Sickle-cell disease. The Lancet. 2010;376(9757):2018-2031.
ABO Blood Group and Susceptibility to Severe Acute Respiratory Syndrome. JAMA. 2005; 293(12):1447.
Zietz M, Zucker J, Tatonetti N. Testing the association between blood type and COVID-19 infection, intubation, and death; 2020.
Li J, Wang X, Chen J, Cai Y, Deng A, Yang M. Association between ABO blood groups and risk of SARS‐CoV‐2 pneumonia. British Journal of Haematology. 2020;190(1):24-7.
Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X et al. Relationship Between the ABO Blood Group and the Coronavirus Disease 2019 (COVID-19) Susceptibility. Clinical Infectious Diseases. 2020;73(2):328-31.
Guillon P, Clément M, Sébille V, Rivain J, Chou C, Ruvoën-Clouet N et al. Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies. Glycobiology. 2008; 18(12):1085-93.
Gérard C, Maggipinto G, Minon J. COVID‐19 and ABO blood group: another viewpoint. British Journal of Haematology. 2020;190(2).
Stussi G, Huggel K, Lutz H, Schanz U, Rieben R, Seebach J. Isotype-specific detection of ABO blood group antibodies using a novel flow cytometric method. British Journal of Haematology. 2005;130(6):954-63.
- Resumen visto - 854 veces
- PDF descargado - 347 veces
- HTML descargado - 1552 veces
Descargas
Licencia
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
Copyright
© Ciencia y Salud, 2021
Afiliaciones
Helio Manuel Grullón Rodríguez
Médico interno. Escuela de Medicina, Pontificia Universidad Católica Madre y Maestra, Santiago de los Caballeros, Santiago, República Dominicana.
Yasmín Céspedes Batista
Escuela de Medicina, (PUCMM).
Lisnaldy Ramírez Osoria
Escuela de Medicina, (PUCMM).
Enmanuel Rosario Díaz
Médico interno. Escuela de Medicina, (PUCMM).
Anthony José Gutiérrez Martínez
Médico general. Escuela de Medicina, (PUCMM).