Cañete R, Gil M. Déficit de hormona de crecimiento. En Pombo A. Tratado de Endocrinología Pediátrica, McGraw-Hill Interamericana de España. Madrid. 2009; 23:284-98.
Isgaard J, Arcopinto M, Karason K, Cittadini A. GH and the cardiovascular system: an update on a topic at heart. Endocrine. 2015;48(1):25-35.
De Leonibus C, De Marco S, Stevens A, Clayton P, Chiarelli F, Monh A. Growth hormone deficiency in prepubertal children: predictive markers of cardiovascular disease. Horm Res Paediatr. 2016;85(6):363-71.
Ramistella V, Wasniewska M, Arasi S, Catena M, Velletri MR, Corica D, et al. Cross-sectional and prospective study of the effects of GH therapy on metabolic panel in children with GH deficiency. Pediatr Med Chir. 2014;36(5):104. Available from https://doi.org/10.4081/pmc.2014.104
Ciresi A, Ciccio F, Amato MC, Giordano C. Revaluation of the clinical and metabolic behavior of children with isolated growth hormone deficiency during GH treatment according to newly proposed note 39 of the Italian Medicines Agency (AIFA). J Endocrinol Investig. 2015;38(12):1301-7.
Meazza C, Elsedfy HH, Pagani S, Bozzola E, El Kholy M, Bozzola M. Metabolic parameters and adipokine profile in growth hormone deficient (GHD) children before and after 12-month GH treatment. Horm Metab Res. 2014;46(3):219-23.
Metwalley KA, Farghaly HS, Abd El-Hafeez HA. Evaluation of left ventricular mass and function, lipid profile, and insulin resistance in Egyptian children with growth hormone deficiency: a single-center prospective case-control study. Indian J EndocrinolMetab. 2013;17 (5):876-82.
Capalbo D, Mattace RG, Esposito A, Di Mase R, Barbieri F, Meli R, et al. Cluster of cardiometabolic risk factors in children with GH deficiency: a prospective, case-control study. Clin Endocrinol (Oxf) 2014;80(6):856-62.
Labarta J, De Arriba A, Ferrer M, Ruiz I, López M, Lou G. Mesa redonda: Hormona de crecimiento y riesgo cardiovascular. Rev Esp Endocrinol Pediatr 2016;7:24-9.
Hernández J, Duchi PN. Índice cintura/talla y su utilidad para detectar riesgo cardiovascular y metabólico. Rev Cubana Endocrinol. 2015;26(1):66-76.
Guía cubana de diagnóstico, evaluación y tratamiento de la hipertensión arterial. La Habana: Revista Cubana de Medicina. 2017;56:49-53.
Instituto Nacional de Endocrinología. Manual de Diagnóstico y Tratamiento en Endocrinología y Metabolismo. La Habana, 2015. (En prensa).
Cabrera E, Marichal S, Parlá J, Arrans C, González R, Pérez C, et al. Frecuencia y características del síndrome metabólico y de la resistencia a la insulina en familiares de primer grado de personas con diabetes mellitus tipo 1. Endocrinol Nutr. 2010;57(7):311-21.
Jellinger PS, Handelsman Y, Rosenblit PD, Bloomgarden ZT, Fonseca VA, Garber AJ, et al. American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Atherosclerosis. Endocr Pract. 2017;23(4):479-97.
Khadilkar V, Ekbote V, Kajale N, Khadilkar A, Chiplonkar S, Kinare A. Effect of one year growth hormone therapy on body composition and cardio-metabolic risk in Indian children with growth hormone deficiency, Endocr. Res. 2014;39:73–8.
Gazzaruso C, Gola M, Karamouzis I, Giubbini R, Giustina A. Cardiovascular risk in adult patients with growth hormone (GH) deficiency and following substitution with GH an update. J Clin Endocrinol Metab. 2014;99:18-29.
Ciresi A, Cicciò F, Radellini S, Giordano C. Utility of C-peptide for a reliable estimate of insulin secretion in children with growth hormone deficiency. Growth Horm IGF Res. 2016;29:71–7.
Abbas K, Saad H, Ahmed H. Evaluation of left ventricular mass and function, lipid profile and insulin resistance in Egyptian children with growth hormone deficiency: A single case-control study. Indian J Endocrinol Metab.2013;17(5):876-82. Doi: 10.4103/2230-8210.117234
Ciresi A, Radellini S, Guarnotta V, Mineo MG, Giordano C. Los resultados metabólicos del tratamiento con hormona de crecimiento en niños son específicos de género. Endocr Connect. 2018;7(7):879-87. Doi: 10.1530 / EC-18-0135
Seminara S, Merello G, Masi S, Filpo A, La Cauza F, D’Onghia G, et al. Effect of long-term growth hormone treatment on carbohydrate metabolism in children with growth hormone deficiency. Clin Endocrinol. 1998;49(1):125–30.
Salerno M, Esposito V, Farina V, Radetti G, Umbaldo A, Capalbo D, et al. Improvement of cardiac performance and cardiovascular risk factors in children with GH deficiency after two years of GH replacement therapy: an observational, open, prospective, case-control study. J Clin Endocrinol Metab. 2006;91(4):1288–95.
Ciresi A, Amato MC, Criscimanna A, Mattina A, Vetro C, Galluzzo A, et al. Metabolic parameters and adipokine profile during GH replacement therapy in children with GH deficiency. Eur J Endocrinol. 2007;156(3):353–60.
López-Siguero JP, López-Canti LF, Espino R, Caro E, Fernández-García JM, Gutiérrez-Macías A, et al. Effect of recombinant growth hormone on leptin, adiponectin, resistin, interleukin-6, tumor necrosis factor-α and ghrelin levels in growth hormone-deficient children. J Endocrinol Invest. 2011;34(4):300–6.
Cañete R, Valle M, Martos R, Sánchez-Carrión A, Cañete MD, van Donkelaar E. Short-term effects of GH treatment on coagulation, fibrinolysis, inflammation biomarkers, and insulin resistance status in prepubertal children with GH deficiency. Eur J Endocrinol. 2012; 167(2):255–60.
Ciresi A, Giordano C. One-hour post-load plasma glucose level is associated with a worse metabolic profile in children with GH deficiency. J Endocrinol Invest. 2018;41:789-97.
Ciresi A, Guarnotta V, Pizzolanti G, Giordano C. Comparison between euglycemic hyperinsulinemic clamp and surrogate indices of insulin sensitivity in children with growth hormone deficiency. Growth Horm IGF Res. 2017;39:40–4.
Ciresi A, Pizzolanti G, Leotta M, Guarnotta V, Teresi G, Giordano C. Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children. J Endocrinol Inves.2016; 39(9):1023–30.
Stawerska R, Smyczyńska J, Hilczer M, Lewiński A. Relationship between IGF-I concentration and metabolic profile in children with growth hormone deficiency: the influence of children’s nutritional state as well as the ghrelin, leptin, adiponectin, and resistin serum concentrations. Int J Endocrinol. 2017; 4:1-9.
De Marco S, Marcovecchio ML, Caniglia D, De Leonibus C, Chiarelli F, Mohn A. Circulating asymmetric dimethylarginine and lipid profile in pre-pubertal children with growth hormone deficiency: effect of 12-month growth hormone replacement therapy. Growth Horm IGF Res. 2014;24(5):216–20.
Xie X, Li Q, Zhang L, Ren W. Lipid accumutation product, visceral adiposity index, and Chinese visceral adiposity index as markers of cardiometabolic risk in adult growth hormone deficiency patients: a cross-sectional study. Endocrine practice. 2018;24(1):33-9.
Uzunova I, Kirilov G, Zacharieva S, Shinkov A, Borissova AM, Kalinov K, et al. Individual risk factors of the metabolic syndrome in adult patients with growth hormona deficiency: A cross-sectional case-control study. Exp Clin Endocrinol Diabetes. 2015;123:39-43.
Chan L, Xue H, Xiaoya Z, Jiajia X, Wei R,Linman L, et al. Lipid accumulation product: a simple and accurate index for predicting Metabolic Syndrome in patients with adult growth hormone deficiency. Exp Clin Endocrinol Diabetes. 2016;124(4):220-4. Doi:10.1055/ s-0035-1569402.
Colao A, Di Somma, Salerno M, Pivonello R, Cuocolo A, SpinelliL, et al. The cardiovascular risk of GH-deficient adolescents. J Clin Endocrinol Metab. 2002;87(8):3650-5.
Witkowska-Sedek E, Rumisnska M, Stelmazezyk-Enmel A, Majcher A, Pyrzak B. The associations between the growth hormone/insulin like growth factor-1 axis, adiponectin, resistin and metabolic profile in children with growth hormone deficiency before and during growth hormone treatment. Acta biochimica polonice. 2018;65(2):333-40.
Prodam F, SavastioS, Genoni G, Babu D, Giordano M, Ricotti R, et al. Effects of growth hormone (GH) therapy withdrawal on glucose metabolism in not confirmed GH deficient adolescents at final height. PLoS One. 2014;9(1):857-71.
Liang S, Xue J, Li G. Effects of recombinant human growth hormone administration on cardiovascular risk factors in obese children with relative growth hormone deficiency. Lipids Health Dis. 2018;17:66. Doi: 10.1186/s12944-018-0721-9
Chen M, Gan D, Luo Y, Rampersad S, Xu Y, Yang S, et al. Effect of recombinant human growth hormone therapy on blood lipid and carotid intima-media thickness in children with growth hormone deficiency. Pediatr Res. 2018;83(5):954-60.
Lippe BM, Kaplan SA, Golden MP, Hendricks SA, Scott ML. Carbohydrate tolerance and insulin receptor binding in children with hypopituitarism: response after acute and chronic human growth hormone administration. J Clin Endocrinol Metab. 1981;53(3):507–13.
Heptulla RA, Boulware SD, Caprio S, Silver D, Sherwin RS, Tamborlane WV. Decreased insulin sensitivity and compensatory hyperinsulinemia after hormone treatment in children with short stature. J Clin Endocrinol Metab. 1997;82(10):3234–8.
Xue Y, Gao Y, Wang S, Wang P. An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency. Exp Ther Med. 2016;11(5):1647–52.
Costa U, Oliveira C, Salvatori R, Barreto-Filho JA, Campos V, Oliveira F, et al. Brazilian adult individuals with untreated isolated GH deficiency do not have acceleratted subclinical atherosclerosis. Endocr connect. 2016;5(1):41-6.
Capalbo D, Esposito A, Improda N, Wasniewska MG, Di Mase R, De Luca F, et al. Glucose homeostasis in GHD children during long-term replacement therapy: a case-control study. Endocrine. 2018;59(3):643–50.
Lanes R. Cardiovascular risk in growth hormone deficiency. Beneficial effects of growth hormone replacement therapy. Endocrinol Metab Clin N Am. 2016;45:405–18.
Ciresi A, Amato MC, Giordano C. Reduction in insulin sensitivity and inadequate β-cell capacity to counteract the increase in insulin resistance in children with idiopathic growth hormone deficiency during 12 months of growth hormone treatment. J Endocrinol Invest.2015;38(3):351-9. Doi: 10.1007/s40618-014-0184-4.
Kubo T, Furujo M, Takahashi K, Hyodo Y, Tsuchiya H, Hattori M, et al. Effects of Growth Hormone Treatment on Lipid Profiles. Indian J Pediatr. 2017;1-5. Available from https://doi.org/10.1007/s12098-017-2509-8
Marcosyan R, Perikhanyan A. Recombinant growth hormone therapy in children with GH deficiency: first interventional study in Armenia. Value in Health.2014;17:336.
Binay C, Simsek E, Yildirim A, Kosger P, Demiral M, Kilic Z.Growth hormone and the risk of atherosclerosis in growth hormone deficient children.Growth Horm IGF Res. 2015;25(6):294-7.
