La anosmia y su interacción en las infecciones causadas por el SARS-CoV2: una revisión
Issue | Vol. 4 Núm. 2 (2021): Ciencia, Ambiente y Clima |
DOI | |
Publicado | dic 17, 2021 |
Estadísticas |
Resumen
La anosmia es uno de los síntomas frecuentes identificados como parte del cuadro clínico de la infección por SARS-CoV2, sin embargo, los mecanismos por los cuales ocurre la disfunción olfatoria no están completamente esclarecidos. Previamente los coronavirus fueron identificados como una familia de virus que pueden causar anosmia, pero en el COVID-19, a diferencia de la familia de los rinovirus, esta no se relaciona con un proceso inflamatorio de la mucosa nasal asociado a obstrucción nasal o rinorrea, lo cual sugiere que la anosmia podría deberse a disturbios en la conducción nerviosa del estímulo olfatorio. La anosmia de los pacientes con COVID-19 recuerda en algunos aspectos al síndrome de Kallman, el cual también cursa con anosmia, su etiología es genética y se debe a mutaciones en el gen ANOS 1 que codifica la molécula de adhesión celular anosmia. En esta revisión se suministrará una recopilación de evidencias fisiopatológicas e interacciones moleculares mediante la cual la proteína anosmia podría modificar el curso de la infección por SARS-CoV2, para ello, se realizó una búsqueda computarizada de literatura para desvendar las posibles relaciones que existen en entre la anosmia y las infecciones causadas por el SARS-CoV2.
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Afiliaciones
Fernanda J. Rodríguez R
Universidad Federal de Pará, 66075-110, Brasil
Edian F. Franco
Instituto Tecnológico de Santo Domingo (INTEC), República Dominicana
Rommel T. Jucá Ramos
Universidad Federal de Pará, 66075-110, Brasil
Maria H. Thomaz Maia
Universidad Federal de Pará, 66075-110, Brasil